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"A new Children's Hospital Medical Center of Cincinnati discovery may
have significant implications for children with a eosinophilic
esophagitis, a fast-growing new disease whose symptoms mimic
gastroesophageal reflux, and for adults with reflux who are not being
helped by currently available medications.
In a study published in the January issue of The Journal of Clinical
Investigation, Marc E. Rothenberg, M.D., Ph.D., has established a link
between reflux and allergy -- not only food allergies but also
environmental allergens such as pollens and molds. Dr. Rothenberg, the
study's senior author, and his colleague Anil Mishra, Ph.D., have
developed the first experimental system, a mouse model, for
eosinophilic esophagitis -- a disease whose numbers have exploded in
recent years.
"We're saying that what a person breathes in can actually affect the
gastrointestinal system," says Dr. Rothenberg, who directs the section
of allergy and clinical immunology in Cincinnati Children's Division
of Pulmonary Medicine, Allergy and Clinical Immunology. "There is a
direct link between exposure to allergens that go to the lung --
aeroallergens -- and development of esophageal inflammation."
http://www.cincinnatichildrens.org/about/news/release/2000/12-allergy-reflux.htm?view=content
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